نمونه ترجمه تخصصی پزشکی درباره التیام زخم

wound healing

Wound healing is an autonomous process that might be interrupted in chronic wounds or burn injuries. Thus, finding a dressing that provides coverage and accelerates healing process while preventing infection is of top priorities [1]. The most important features that a suitable dressing must have are preservation of adequate humidity at the would surface, transfer of active combinations, prevention of formation of microbial biofilms, easing pain and inflation, debride dead and damages tissues, and facilitation of reaction between the cells and proteins that can be effective on wound adjustment and healing [2, 3]. Since no known material can possess all these specifications, a combination of biopolymers are used to improve wound healing process. Sasikala et al. proposed chitosan hydrogel membrane and honey as wound dressing [4]. Wang et al. (2012) utilized chitosan hydrogel, honey, and gelatin with 20:20:0.5 ratio and obtained the best results in antibacterial and toxicity tests. In addition, the mixture had a significant effect on contraction of wound and acceleration of healing process [5]. Sfandiari et al. (2017) used chitosan/collagen/Aloe Vera, as a suitable coverage combination for burns with high cells proliferation performance [6]. Ielani et al. used chitosan and Aloe Vera gel to produce nanofiber [7]. One of the most suitable biopolymers for modern dressing solutions is chitosan. It is a natural, non-toxic, biocompatible, and biodegradable polymer with wound healing effects [8]. One of the unique specification of chitosan is its ability to accelerate formation of granulated tissue along with angiogenesis and orderly sedimentation of fine collagen tissue that leads to complete wound healing. The main biochemical effects of chitosan are activating fibroblasts of cytokine generator, facilitating migration of large cells, and triggering synthesis of collagen type V [9]. Chitosan with low and average molecular weights was used for producing fine film and nano-fiber respectively. Chitosan/gelatin film is the base for chitosan nano-fiber/polyethylene oxide and improves many of its characteristics. Due to arg-Gly-Asp (RGD) sequence, biological functions of chitosan – e.g. adhesiveness, cellular migration - are improved when it is combined with gelatin. In addition, hydrophilic feature of gelatin ensures that the wound is kept moisturized and nutrient and oxygen are available to the wound [10].