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recurrence and more than one-year survival rate in Hodgkin lymphoma patients

Hodgkin Lymphoma (HL) is a cancer that starts from immunity system cells (1). Prevalence of the disease in the developed countries is higher than Asian countries (2). It has a wide geographical distribution so that a study in the USA between 2009 and 2013 reported a prevalence rate of 6.2 in every 100 thousand individuals (3). The disease is also featured with age peak so that the first peak is between 15 and 34 years and the second peak is in 54th year (4). The cause of HL is unknown and many studies have blamed genetical potential (5). There is a relationship between HL and HLA antigens (6). In general, HL patients demonstrate peripheral lymphadenopathy and enlarged lymphatic glands is the most common clinical expression in young patients. The most common spots of expression are cervical and supraclavicular lymph glands following by the armpit and upper parts of the neck (7). Diagnosis of HL is based on examining biopsy samples of lymph glands by a pathologist (8). After diagnosis, staging measures including CBC, ESR, LDH, CXR, abdominal and pelvic CT-SCAN, aspiration, marrow biopsy, PET scan, and/or Gallium scan are carried out (9). Over the past few years, technological advances have come to help us in diagnosing and treating diseases. Proper use of such technologies can lead to a better diagnosis and more efficient treatment (10). The PET scan is a non-invasive, complicated, and expensive medical imaging technology that is used to diagnose and treat various diseases like a variety of cancers, cardiovascular diseases, and neurological diseases (11). The technique reveals cellular function and molecular process and it can trace the process in living organisms without any damage or risk to the cells. Molecular imaging includes fluorescence imaging, bioluminescent imaging, positron emission tomography (PET), single photon emission compound tomography (SPECT), and magnetic resonance imaging (MRI). These imaging technologies play a key role in finding and study tumors (12). Thanks to technological advances, physicians are able not only to localize the tumors but also examine activity of biological processes inside the tumors, which enables them to perform ‘on the spot’ treatment (13). By causing 40% change in treatment performance, PET imaging plays a notable role in medicine (14).